Cialis drug interactions
Cialis · tadalafil · by Eli Lilly
Interaction lookup
Search by medication name or drug class to see clinically meaningful Cialis interactions.
Nitrates
MajorClass: nitrate
Severe hypotension — never combine. Tadalafil's long half-life means the 24-hour rule extends to 48 hours after the last dose.
Alpha-blockers
ModerateClass: alpha-blocker
Hypotension risk; lower starting dose, stable alpha-blocker regimen required.
Ritonavir
MajorClass: CYP3A4 inhibitor
Maximum 10 mg every 72 hours; significant exposure increase.
Editorial table from FDA labels + drug compendia. Not exhaustive. Discuss any concurrent medication, supplement, or condition with your prescriber before starting or stopping treatment.
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People also ask
Frequently asked
What medications interact with Cialis?+
Same critical contraindication as Viagra: nitrates can cause life-threatening hypotension. Never combine. Caution with alpha-blockers and CYP3A4 inhibitors. Daily low-dose Cialis (2.5-5mg) has the same interaction profile as as-needed dosing — same drugs to avoid, same monitoring.
Can I take Cialis with metformin?+
Cialis and metformin are commonly co-prescribed without major interaction concerns. GI side effects may be additive in some patients.